Sr. Scientist, Translational Biology (In vitro & in vivo)
Flagship Pioneering
Company Summary:
FL115 Inc., is a privately held, early-stage biotechnology company developing a novel delivery platform to enhance delivery of therapeutics across biological barriers. Our platform integrates experimental and computational approaches to unlock spatiotemporally controlled delivery of payloads to any tissue or cell type, unlocking effective treatment for a wide range of high unmet-need diseases and enabling new medicines.
FL115 is a Flagship Pioneering company. Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple transformative human health and sustainability products. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures. The current Flagship ecosystem comprises over 40 companies, including Denali Therapeutics, Moderna, Generate:Biomedicines, Lila Sciences, Indigo Agriculture, and Tessera Therapeutics.
Position Summary:
FL115 is seeking a highly motivated Sr. Scientist in Translational Biology (In vitro & in vivo) to play a vital role in the company’s efforts to develop a range of biological assays for assessment of a novel drug delivery technology. The candidate must be independent, goal oriented, have excellent communication skills and be willing to work in a highly dynamic and fast-paced entrepreneurial environment. This is a unique opportunity to drive the growth of an early-stage biotechnology company where you can contribute to the next frontier of genetic medicines. We are looking for collaborative, enthusiastic problem-solvers to join our team, driven by a shared goal of making a practical impact.
Core Responsibilities:
- Conceptualize and execute on biological assays relevant for validation of novel delivery technology (e.g. efficacy of gene therapy, biological barrier disruption, safety/toxicity)
- Manage & engage with relevant CROs and external parties to execute assays
- Design and execute mouse experiments and protocols
- Maintain mammalian cell culture lines and perform downstream experiments
- Work collaboratively in an interdisciplinary scientific team to develop experimental plans
- Contribute to development of scientific strategy
- Effectively communicate scientific results to the team through engaging presentations and clear, concise discussions. Document results in an ELN
- Stay at the forefront of scientific advancements by actively monitoring current literature and sharing key insights with the broader team.
Qualifications and Skills:
- PhD in Cell Biology, Gene Therapy, Immunology or related field, with 2+ years of experience in biopharmaceutical industry preferred.
- Hands-on experience in mammalian cell culture and using various delivery technologies (e.g. transfection, nucleofection, Messenger Max, RNAi etc).
- Experience with protein and/or nucleic acid (DNA/RNA) isolation from mammalian cells and tissues, cDNA synthesis, and qPCR is essential.
- Experience with biological assay development and troubleshooting.
- Candidates of various experience levels will be considered. Position to be determined commensurate with experience.
Additional Qualifications (preferred but not required):
- Experience with RNAseq and associated analysis is a plus
- Experience with delivery technologies such as LNP, AAV, nucleic acid delivery, in vivo electroporation
- Experience generating cell lines using lentivirus
- Experience with various ELN systems (e.g. Benchling)
About Flagship
Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
